Small molecule KDM4s inhibitors as anti-cancer agents.
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ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC6010108 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Small molecule KDM4s inhibitors as anti-cancer agents.
Lin Hongzhi H Li Qihang Q Li Qi Q Zhu Jie J Gu Kai K Jiang Xueyang X Hu Qianqian Q Feng Feng F Qu Wei W Chen Yao Y Sun Haopeng H
Journal of enzyme inhibition and medicinal chemistry 20181201 1
Histone demethylation is a vital process in epigenetic regulation of gene expression. A number of histone demethylases are present to control the methylated states of histone. Among these enzymes, KDM4s are one subfamily of JmjC KDMs and play important roles in both normal and cancer cells. The discovery of KDM4s inhibitors is a potential therapeutic strategy against different diseases including cancer. Here, we summarize the development of KDM4s inhibitors and some related pharmaceutical inform ...[more]
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