Deriving dopaminergic neurons for clinical use. A practical approach.
Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez R
PROVIDER: S-EPMC3597995 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Deriving dopaminergic neurons for clinical use. A practical approach.
Gonzalez Rodolfo R Garitaonandia Ibon I Abramihina Tatiana T Wambua Gerald K GK Ostrowska Alina A Brock Mathew M Noskov Alexander A Boscolo Francesca S FS Craw John S JS Laurent Louise C LC Snyder Evan Y EY Semechkin Ruslan A RA
Scientific reports 20130101
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients. ...[more]
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