Dataset Information

Deriving dopaminergic neurons for clinical use. A practical approach.

ABSTRACT: New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.

SUBMITTER: Gonzalez R

PROVIDER: S-EPMC3597995 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Deriving dopaminergic neurons for clinical use. A practical approach.

Gonzalez Rodolfo R Garitaonandia Ibon I Abramihina Tatiana T Wambua Gerald K GK Ostrowska Alina A Brock Mathew M Noskov Alexander A Boscolo Francesca S FS Craw John S JS Laurent Louise C LC Snyder Evan Y EY Semechkin Ruslan A RA

Scientific reports 20130101

New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients. ...[more]

PMID: 23492920

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Dataset Information

Deriving dopaminergic neurons for clinical use. A practical approach.

Publications

Deriving dopaminergic neurons for clinical use. A practical approach.

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