Ontology highlight
ABSTRACT:
SUBMITTER: Lee K
PROVIDER: S-EPMC3601783 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lee Kyungae K Ren Tao T Côté Marceline M Gholamreza Berahman B Misasi John J Bruchez Anna A Cunningham James J
ACS medicinal chemistry letters 20121219 2
A high throughput screen identified adamantane dipeptide <b>1</b> as an inhibitor of Ebola virus (EboV) infection. Hit-to-lead optimization to determine the structure-activity relationship (SAR) identified the more potent EboV inhibitor <b>2</b> and a photoaffinity labeling agent <b>3</b>. These anti-viral compounds were employed to identify the target as Niemann-Pick C1 (NPC1), a host protein that binds the EboV glycoprotein and is essential for infection. These studies establish NPC1 as a prom ...[more]