Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC7111281 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Wang Han H Shi Yi Y Song Jian J Qi Jianxun J Lu Guangwen G Yan Jinghua J Gao George F GF
Cell 20160101 1-2
Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in humans and primates. Understanding how these viruses enter host cells could help to develop effective therapeutics. An endosomal protein, Niemann-Pick C1 (NPC1), has been identified as a necessary entry receptor for this process, and priming of the viral glycoprotein (GP) to a fusion-competent state is a prerequisite for NPC1 binding. Here, we have determined the crystal structure of the primed GP (GPcl) of Ebola virus bo ...[more]