Ontology highlight
ABSTRACT:
SUBMITTER: Marvin RG
PROVIDER: S-EPMC3601789 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Marvin Rebecca G RG Wolford Janet L JL Kidd Matthew J MJ Murphy Sean S Ward Jesse J Que Emily L EL Mayer Meghan L ML Penner-Hahn James E JE Haldar Kasturi K O'Halloran Thomas V TV
Chemistry & biology 20120601 6
Dynamic fluxes in the concentration of ions and small molecules are fundamental features of cell signaling, differentiation, and development. Similar roles for fluxes in transition metal concentrations are less well established. Here, we show that massive zinc fluxes are essential in the infection cycle of an intracellular eukaryotic parasite. Using single-cell quantitative imaging, we show that growth of the blood-stage Plasmodium falciparum parasite requires acquisition of 30 million zinc atom ...[more]