Ontology highlight
ABSTRACT:
SUBMITTER: Simao-Gurge RM
PROVIDER: S-EPMC6917786 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Simão-Gurge Raquel M RM Wunderlich Gerhard G Cricco Julia A JA Cubillos Eliana F Galindo EFG Doménech-Carbó Antonio A Cebrián-Torrejón Gerardo G Almeida Fernando G FG Cirulli Brenda A BA Katzin Alejandro M AM
Scientific reports 20191217 1
A number of antimalarial drugs interfere with the electron transport chain and heme-related reactions; however, the biosynthesis of heme derivatives in Plasmodium parasites has not been fully elucidated. Here, we characterized the steps that lead to the farnesylation of heme. After the identification of a gene encoding heme O synthase, we identified heme O synthesis in blood stage parasites through the incorporation of radioactive precursors. The presence of heme O synthesis in intraerythrocytic ...[more]