Ontology highlight
ABSTRACT:
SUBMITTER: Manfe V
PROVIDER: S-EPMC3602111 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Manfè Valentina V Biskup Edyta E Willumsgaard Ayalah A Skov Anne Guldhammer AG Palmieri Dario D Gasparini Pierluigi P Laganá Alessandro A Woetmann Anders A Ødum Niels N Croce Carlo Maria CM Gniadecki Robert R
PloS one 20130319 3
Successful/effective cancer therapy in low grade lymphoma is often hampered by cell resistance to anti-neoplastic agents. The crucial mechanisms responsible for this phenomenon are poorly understood. Overcoming resistance of tumor cells to anticancer agents, such as proteasome inhibitors, could improve their clinical efficacy. Using cutaneous T-cell lymphoma (CTCL) as a model of the chemotherapy-resistant peripheral lymphoid malignancy, we demonstrated that resistance to proteasome inhibition in ...[more]