Dataset Information

Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis.

ABSTRACT:

Background

Matrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.

Methods

Retrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and periodontitis susceptibility were included into the final analysis with definite selection and exclusion criteria. Overall and stratified analyses based on disease type, severity, ethnicity and smoking status were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between MMP-1 g.-1607dupG and periodontitis susceptibility, while Q test and Egger's test were adopted respectively to assess heterogeneity among studies and publication bias.

Results

A total of 1580 periodontitis cases and 1386 controls in 11 case-control studies were included in the meta-analysis. The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR?=?1.50, 95% CI?=?1.02-2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR?=?1.28, 95% CI?=?1.04-1.57). For subgroups by type of periodontitis, increased risk of chronic periodontitis was observed on heterozygote (2G/1G versus 1G/1G, OR?=?2.01, 95% CI?=?1.58-2.56) and dominant model (OR?=?1.27, 95% CI?=?1.03-1.57). Furthermore, similar association was also detected in severe chronic periodontitis (2G/2G versus 1G/1G, OR?=?2.15, 95% CI?=?1.35-3.43; 2G/2G+2G/1G versus 1G/1G, OR?=?1.64, 95% CI?=?1.12-2.39; 2G/2G versus 2G/1G+1G/1G, OR?=?1.86, 95% CI?=?1.31-2.64).

Conclusions

Our meta-analysis demonstrated that MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.

SUBMITTER: Li D

PROVIDER: S-EPMC3603913 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis.

Li Dandan D Cai Qi Q Ma Lan L Wang Meilin M Ma Junqing J Zhang Weibing W Pan Yongchu Y Wang Lin L

PloS one 20130320 3

<h4>Background</h4>Matrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.<h4>Methods</h4>Retrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and p ...[more]

PMID: 23527212

Similar Datasets

Project description:BackgroundAlthough many studies have focused on the association of the MMP-9 promoter -1562 C/T polymorphism with the susceptibility and/or severity of chronic periodontitis (CP), results have been inconsistent. Therefore, a meta-analysis of all eligible studies was performed to derive a more precise estimation of the association between this polymorphism and CP risk.MethodsAll relevant studies were identified through a database search in PubMed, Medline, and Web of Science. All the full-text studies with appropriate analytical design, published in English, which evaluated the association of MMP-9 promoter -1562C/T polymorphism with CP risk using validated genotyping methods, and with non-duplicated data were selected for this study. A fixed-effect model was used to calculate pooled ORs in the absence of heterogeneity across included trials (P > 0.1 and I(2) < 50 %), otherwise the random-effect model was applied.ResultsIn an overall meta-analysis, pooled ORs revealed that T variant in the MMP-9 promoter -1562 C/T polymorphism was associated with a significantly decreased risk for CP under all comparison models. In subgroup analyses by ethnicity, pooled ORs showed that a significant association of the MMP-9 promoter -1562 C/T polymorphism with CP risk was only detected in Caucasians and Asians but not in mixed population. In the subgroup analysis by severity of CP, pooled ORs indicated that T allele of the MMP-9 promoter -1562 C/T polymorphism was associated with decreased susceptibility to severe CP while there was no significant association between this polymorphism and moderate CP.ConclusionsOur meta-analysis showed that T allele in the MMP-9 promoter -1562 C/T polymorphism might be a protective factor for CP, especially in Caucasians and Asians. Moreover, there was a significant association of the MMP-9 promoter -1562 C/T polymorphism with decreased susceptibility to severe CP, while the allelic and/or genotype distributions of this polymorphism were not associated with moderate CP.

Dataset Information

Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis.

Background

Methods

Results

Conclusions

Publications

Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis.

Similar Datasets

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