Dataset Information

TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.

ABSTRACT: Many primary and secondary studies reported the association between Toll-like receptor 4 (TLR4) polymorphism and periodontitis susceptibility, which mainly focused on TLR4-299A>G or TLR4-399C>T of Caucasian, however, these studies had different conclusions. The aim of this study was to reassess relative studies about TLR4 polymorphism and periodontitis susceptibility, and update meta-analysis.We searched the electronic database including CNKI (Chinese National Knowledge Infrastructure), PubMed, Embase, and hand searched relative studies until January 4, 2016. Two authors selected studies according to inclusion and exclusion criteria, assessed studies using Newcastle-Ottawa Scale case control study (NOS), and calculated the combined effect size using STATA software, version 12.0.This meta-analysis included 18 studies, containing 2453 healthy participants and 2987 patients with chronic periodontitis (CP) and 462 patients with aggressive periodontitis (AP). There was a significance between TLR4C>G (rs7873784) allele and CP in Asian, and its recessive model was also significant (for C vs G: odds ratio [OR] = 0.72, 95% confidence interval [CI] = 0.54-0.95, I = 0%; for CC?+?CG vs GG: OR = 0.66, 95% CI = 0.49-0.89, I = 0%). However, we did not detect any significant relevance between other TLR4 polymorphism and periodontitis susceptibility in overall and subgroup analyses. The sensitive analysis showed that dropping any single studies did not affect the pooled-analysis results. Publication bias was not detected.The meta-analysis found association between TLR4C>G (rs7873784) allele and CP in Asian and it may passed on to offsprings in the form of recessiveness. However, further studies about the association between TLR4C>G (rs7873784) and CP is warranted to confirm.

SUBMITTER: Jin SH

PROVIDER: S-EPMC5023927 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.

Jin Su-Han SH Guan Xiao-Yan XY Liang Wen-Hong WH Bai Guo-Hui GH Liu Jian-Guo JG

Medicine 20160901 36

<h4>Background</h4>Many primary and secondary studies reported the association between Toll-like receptor 4 (TLR4) polymorphism and periodontitis susceptibility, which mainly focused on TLR4-299A>G or TLR4-399C>T of Caucasian, however, these studies had different conclusions. The aim of this study was to reassess relative studies about TLR4 polymorphism and periodontitis susceptibility, and update meta-analysis.<h4>Methods</h4>We searched the electronic database including CNKI (Chinese National ...[more]

PMID: 27603404

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Project description:BackgroundMatrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.MethodsRetrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and periodontitis susceptibility were included into the final analysis with definite selection and exclusion criteria. Overall and stratified analyses based on disease type, severity, ethnicity and smoking status were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between MMP-1 g.-1607dupG and periodontitis susceptibility, while Q test and Egger's test were adopted respectively to assess heterogeneity among studies and publication bias.ResultsA total of 1580 periodontitis cases and 1386 controls in 11 case-control studies were included in the meta-analysis. The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR?=?1.50, 95% CI?=?1.02-2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR?=?1.28, 95% CI?=?1.04-1.57). For subgroups by type of periodontitis, increased risk of chronic periodontitis was observed on heterozygote (2G/1G versus 1G/1G, OR?=?2.01, 95% CI?=?1.58-2.56) and dominant model (OR?=?1.27, 95% CI?=?1.03-1.57). Furthermore, similar association was also detected in severe chronic periodontitis (2G/2G versus 1G/1G, OR?=?2.15, 95% CI?=?1.35-3.43; 2G/2G+2G/1G versus 1G/1G, OR?=?1.64, 95% CI?=?1.12-2.39; 2G/2G versus 2G/1G+1G/1G, OR?=?1.86, 95% CI?=?1.31-2.64).ConclusionsOur meta-analysis demonstrated that MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.

Project description:BackgroundAlthough many studies have focused on the association of the MMP-9 promoter -1562 C/T polymorphism with the susceptibility and/or severity of chronic periodontitis (CP), results have been inconsistent. Therefore, a meta-analysis of all eligible studies was performed to derive a more precise estimation of the association between this polymorphism and CP risk.MethodsAll relevant studies were identified through a database search in PubMed, Medline, and Web of Science. All the full-text studies with appropriate analytical design, published in English, which evaluated the association of MMP-9 promoter -1562C/T polymorphism with CP risk using validated genotyping methods, and with non-duplicated data were selected for this study. A fixed-effect model was used to calculate pooled ORs in the absence of heterogeneity across included trials (P > 0.1 and I(2) < 50 %), otherwise the random-effect model was applied.ResultsIn an overall meta-analysis, pooled ORs revealed that T variant in the MMP-9 promoter -1562 C/T polymorphism was associated with a significantly decreased risk for CP under all comparison models. In subgroup analyses by ethnicity, pooled ORs showed that a significant association of the MMP-9 promoter -1562 C/T polymorphism with CP risk was only detected in Caucasians and Asians but not in mixed population. In the subgroup analysis by severity of CP, pooled ORs indicated that T allele of the MMP-9 promoter -1562 C/T polymorphism was associated with decreased susceptibility to severe CP while there was no significant association between this polymorphism and moderate CP.ConclusionsOur meta-analysis showed that T allele in the MMP-9 promoter -1562 C/T polymorphism might be a protective factor for CP, especially in Caucasians and Asians. Moreover, there was a significant association of the MMP-9 promoter -1562 C/T polymorphism with decreased susceptibility to severe CP, while the allelic and/or genotype distributions of this polymorphism were not associated with moderate CP.

Dataset Information

TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.

Publications

TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.

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