Ontology highlight
ABSTRACT:
SUBMITTER: Ashare RL
PROVIDER: S-EPMC3604077 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
The pharmacogenomics journal 20121218 6
Possessing an apolipoprotein E (APOE) ɛ4 allele, advanced age and smoking are risk factors for Alzheimer's disease and cognitive decline. Deficits in cognitive function also increase risk for smoking relapse. Data from 917 adult smokers of European ancestry were pooled across three randomized trials of smoking cessation. We examined whether smokers who carry at least one ɛ4 allele (n=252) have more difficulty quitting smoking compared with noncarriers (n=665), and whether age moderated this asso ...[more]