Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
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ABSTRACT:
SUBMITTER: Han K
PROVIDER: S-EPMC3605462 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
Han Kihoon K Gennarino Vincenzo Alessandro VA Lee Yoontae Y Pang Kaifang K Hashimoto-Torii Kazue K Choufani Sanaa S Raju Chandrasekhar S CS Oldham Michael C MC Weksberg Rosanna R Rakic Pasko P Liu Zhandong Z Zoghbi Huda Y HY
Genes & development 20130221 5
Proper neurological function in humans requires precise control of levels of the epigenetic regulator methyl CpG-binding protein 2 (MeCP2). MeCP2 protein levels are low in fetal brains, where the predominant MECP2 transcripts have an unusually long 3' untranslated region (UTR). Here, we show that miR-483-5p, an intragenic microRNA of the imprinted IGF2, regulates MeCP2 levels through a human-specific binding site in the MECP2 long 3' UTR. We demonstrate the inverse correlation of miR-483-5p and ...[more]
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