Ontology highlight
ABSTRACT:
SUBMITTER: Ma C
PROVIDER: S-EPMC3606245 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ma Chi C Muranyi Marianna M Chu Catherine H CH Zhang Jianhua J Chu Wen-Ming WM
PloS one 20130322 3
CpG-ODN stimulates dendritic cells (DCs) to produce cytokines, which are important for pathogenesis of autoimmune disorders and vaccine strategy for cancer. CpG-ODN activates the TLR9/MyD88/TRAF6 cascade leading to activation of IKK-NF-κB and JNK, which are critical for production of pro-inflammatory cytokines. However, whether other molecules are involved in activation of CpG-ODN signaling is still not clear. Here we report that the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) i ...[more]