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Enhancing the Cellular Delivery of Nanoparticles using Lipo-Oligoarginine Peptides.

ABSTRACT: Nanoparticles have great potential as nanotherapeutics, delivery vectors, and molecular imaging agents due to their flexible properties. Although intracellular and nuclear delivery of nanoparticles is desirable for therapeutic applications, it remains a challenge. Cell penetrating peptides (CPPs) are a powerful tool for the intracellular delivery of various cargoes. Here we report that functionalization of nanoparticles with a myristoylated oligoarginine CPP promoted cellular uptake without increased toxicity. It was evidenced that the myristoylated CPP is much more effective in transporting nanoparticles than the unmodified CPPs.

SUBMITTER: Lee JS

PROVIDER: S-EPMC3607535 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Enhancing the Cellular Delivery of Nanoparticles using Lipo-Oligoarginine Peptides.

Lee Jae Sam JS Tung Ching-Hsuan CH

Advanced functional materials 20120727 23

Nanoparticles have great potential as nanotherapeutics, delivery vectors, and molecular imaging agents due to their flexible properties. Although intracellular and nuclear delivery of nanoparticles is desirable for therapeutic applications, it remains a challenge. Cell penetrating peptides (CPPs) are a powerful tool for the intracellular delivery of various cargoes. Here we report that functionalization of nanoparticles with a myristoylated oligoarginine CPP promoted cellular uptake without incr ...[more]

PMID: 23538989

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