Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC5812013 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Advanced materials (Deerfield Beach, Fla.) 20180108 7
Clinical translation of therapeutic peptides, particularly those that require penetration of the cell membrane or are cytolytic, is a major challenge. A novel approach based on a complementary mechanism, which has been widely used for guided synthesis of DNA or RNA nanoparticles, for de novo design of activatable protein nanoparticles (APNPs) for targeted delivery of therapeutic peptides is described. APNPs are formed through self-assembly of three independent polypeptides based on pairwise coil ...[more]