Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3614094 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Zhang Yi Y Cheng Yan Y Ren Xingcong X Hori Tsukasa T Huber-Keener Kathryn J KJ Zhang Li L Yap Kai Lee KL Liu David D Shantz Lisa L Qin Zheng-Hong ZH Zhang Suping S Wang Jianrong J Wang Hong-Gang HG Shih Ie-Ming IeM Yang Jin-Ming JM
Cancer research 20120604 16
Nucleus accumbens-1 (NAC1), a nuclear factor belonging to the BTB/POZ gene family, has emerging roles in cancer. We report here that NAC1 acts as a negative regulator of cellular senescence in transformed and nontransformed cells, and dysfunction of NAC1 induces senescence and inhibits its oncogenic potential. We show that NAC1 deficiency markedly activates senescence and inhibits proliferation in tumor cells treated with sublethal doses of γ-irradiation. In mouse embryonic fibroblasts from NAC1 ...[more]