Ontology highlight
ABSTRACT:
SUBMITTER: Evangelou E
PROVIDER: S-EPMC3615180 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Evangelou Evangelos E Valdes Ana M AM Kerkhof Hanneke J M HJ Styrkarsdottir Unnur U Zhu Yanyan Y Meulenbelt Ingrid I Lories Rik J RJ Karassa Fotini B FB Tylzanowski Przemko P Bos Steffan D SD Akune Toru T Arden Nigel K NK Carr Andrew A Chapman Kay K Cupples L Adrienne LA Dai Jin J Deloukas Panos P Doherty Michael M Doherty Sally S Engstrom Gunnar G Gonzalez Antonio A Halldorsson Bjarni V BV Hammond Christina L CL Hart Deborah J DJ Helgadottir Hafdis H Hofman Albert A Ikegawa Shiro S Ingvarsson Thorvaldur T Jiang Qing Q Jonsson Helgi H Kaprio Jaakko J Kawaguchi Hiroshi H Kisand Kalle K Kloppenburg Margreet M Kujala Urho M UM Lohmander L Stefan LS Loughlin John J Luyten Frank P FP Mabuchi Akihiko A McCaskie Andrew A Nakajima Masahiro M Nilsson Peter M PM Nishida Nao N Ollier William E R WE Panoutsopoulou Kalliope K van de Putte Tom T Ralston Stuart H SH Rivadeneira Fernado F Saarela Janna J Schulte-Merker Stefan S Shi Dongquan D Slagboom P Eline PE Sudo Akihiro A Tamm Agu A Tamm Ann A Thorleifsson Gudmar G Thorsteinsdottir Unnur U Tsezou Aspasia A Wallis Gillian A GA Wilkinson J Mark JM Yoshimura Noriko N Zeggini Eleftheria E Zhai Guangju G Zhang Feng F Jonsdottir Ingileif I Uitterlinden Andre G AG Felson David T DT van Meurs Joyce B JB Stefansson Kari K Ioannidis John P A JP Spector Timothy D TD
Annals of the rheumatic diseases 20101110 2
<h4>Objectives</h4>Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component.<h4>Methods</h4>A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian popul ...[more]