Ontology highlight
ABSTRACT:
SUBMITTER: Strunk BS
PROVIDER: S-EPMC3615461 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Strunk Bethany S BS Novak Megan N MN Young Crystal L CL Karbstein Katrin K
Cell 20120701 1
Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs are displaced from maturing 40S ribosomes, if or how maturing subunits are assessed for fidelity, and what prevents premature translation initiation once AFs dissociate. Here we show that maturation involves a translation-like cycle whereby the translation factor eIF5B, a GTPase, promotes joining of large (60S) subunits ...[more]