Ontology highlight
ABSTRACT:
SUBMITTER: Serrentino ME
PROVIDER: S-EPMC3616913 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Serrentino Maria-Elisabetta ME Chaplais Emmanuel E Sommermeyer Vérane V Borde Valérie V
PLoS genetics 20130404 4
During the first meiotic prophase, programmed DNA double-strand breaks (DSBs) are distributed non randomly at hotspots along chromosomes, to initiate recombination. In all organisms, more DSBs are formed than crossovers (CO), the repair product that creates a physical link between homologs and allows their correct segregation. It is not known whether all DSB hotspots are also CO hotspots or if the CO/DSB ratio varies with the chromosomal location. Here, we investigated the variations in the CO/D ...[more]