Ontology highlight
ABSTRACT:
SUBMITTER: Goto T
PROVIDER: S-EPMC3618174 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Goto Toshiyasu T Sato Atsushi A Shimizu Masahiro M Adachi Shungo S Satoh Kiyotoshi K Iemura Shun-ichiro S Natsume Tohru T Shibuya Hiroshi H
PloS one 20130405 4
Dishevelled (DVL) is a central factor in the Wnt signaling pathway, which is highly conserved among various organisms. DVL plays important roles in transcriptional activation in the nucleus, but the molecular mechanisms underlying their nuclear localization remain unclear. In the present study, we identified IQGAP1 as a regulator of DVL function. In Xenopus embryos, depletion of IQGAP1 reduced Wnt-induced nuclear accumulation of DVL, and expression of Wnt target genes during early embryogenesis. ...[more]