Sarcopenia and body mass index predict sunitinib-induced early dose-limiting toxicities in renal cancer patients.
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ABSTRACT: Background
Little is known on factors predicting sunitinib toxicity. Recently, the condition of low muscle mass, named sarcopenia, was identified as a significant predictor of toxicity in metastatic renal cell cancer (mRCC) patients treated with sorafenib. We investigated whether sarcopenia could predict early dose-limiting toxicities (DLTs) occurrence in mRCC patients treated with sunitinib.Methods
Consecutive mRCC patients treated with sunitinib were retrospectively reviewed. A DLT was defined as any toxicity leading to dose reduction or treatment discontinuation. Body composition was evaluated using CT scan obtained within 1 month before treatment initiation.Results
Among 61 patients eligible for analysis, 52.5% were sarcopenic and 32.8% had both sarcopenia and a body mass index (BMI)<25?kg?m(-2). Eighteen patients (29.5%) experienced a DLT during the first cycle. Sarcopenic patients with a BMI<25?kg?m(-2) experienced more DLTs (P=0.01; odds ratio=4.1; 95% CI: (1.3-13.3)), more cumulative grade 2 or 3 toxicities (P=0.008), more grade 3 toxicities (P=0.04) and more acute vascular toxicities (P=0.009).Conclusion
Patients with sarcopenia and a BMI<25?kg?m(-2) experienced significantly more DLTs during the first cycle of treatment.
SUBMITTER: Huillard O
PROVIDER: S-EPMC3619075 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Sarcopenia and body mass index predict sunitinib-induced early dose-limiting toxicities in renal cancer patients.
Huillard O O Mir O O Peyromaure M M Tlemsani C C Giroux J J Boudou-Rouquette P P Ropert S S Delongchamps N Barry NB Zerbib M M Goldwasser F F
British journal of cancer 20130305 5
<h4>Background</h4>Little is known on factors predicting sunitinib toxicity. Recently, the condition of low muscle mass, named sarcopenia, was identified as a significant predictor of toxicity in metastatic renal cell cancer (mRCC) patients treated with sorafenib. We investigated whether sarcopenia could predict early dose-limiting toxicities (DLTs) occurrence in mRCC patients treated with sunitinib.<h4>Methods</h4>Consecutive mRCC patients treated with sunitinib were retrospectively reviewed. A ...[more]
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