Ontology highlight
ABSTRACT:
SUBMITTER: Yu L
PROVIDER: S-EPMC3621671 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Yu Lisa L Thakur Satbir S Leong-Quong Rebecca Yy RY Suzuki Keiko K Pang Andy A Bjorge Jeffrey D JD Riabowol Karl K Fujita Donald J DJ
PloS one 20130409 4
The INhibitor of Growth 1 (ING1) is stoichiometric member of histone deacetylase (HDAC) complexes and functions as an epigenetic regulator and a type II tumor suppressor. It impacts cell growth, aging, apoptosis, and DNA repair, by affecting chromatin conformation and gene expression. Down regulation and mislocalization of ING1 have been reported in diverse tumor types and Ser/Thr phosphorylation has been implicated in both of these processes. Here we demonstrate that both in vitro and in vivo, ...[more]