Ontology highlight
ABSTRACT:
SUBMITTER: Chiu YH
PROVIDER: S-EPMC4004185 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Chiu Yu-Hsin YH Lee Jennifer Y JY Cantley Lewis C LC
Molecular cell 20140320 1
Phosphoinositide 3-kinase (PI3K) activity is important for regulating cell growth, survival, and motility. We report here the identification of bromodomain-containing protein 7 (BRD7) as a p85α-interacting protein that negatively regulates PI3K signaling. BRD7 binds to the inter-SH2 (iSH2) domain of p85 through an evolutionarily conserved region located at the C terminus of BRD7. Via this interaction, BRD7 facilitates nuclear translocation of p85α. The BRD7-dependent depletion of p85 from the cy ...[more]