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Adhesins in human fungal pathogens: glue with plenty of stick.


ABSTRACT: Understanding the pathogenesis of an infectious disease is critical for developing new methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to host tissue is a prerequisite for tissue invasion and infection. Fungal cell wall adhesins involved in adherence to host tissue or abiotic medical devices are critical for colonization leading to invasion and damage of host tissue. Here, with a main focus on pathogenic Candida species, we summarize recent progress made in the field of adhesins in human fungal pathogens and underscore the importance of these proteins in establishment of fungal diseases.

SUBMITTER: de Groot PW 

PROVIDER: S-EPMC3623432 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Adhesins in human fungal pathogens: glue with plenty of stick.

de Groot Piet W J PW   Bader Oliver O   de Boer Albert D AD   Weig Michael M   Chauhan Neeraj N  

Eukaryotic cell 20130208 4


Understanding the pathogenesis of an infectious disease is critical for developing new methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to host tissue is a prerequisite for tissue invasion and infection. Fungal cell wall adhesins involved in adherence to host tissue or abiotic medical devices are critical for colonization leading to invasion and damage of host tissue. Here, with a main focus on pathogenic Candida species, we summarize recent progress made in  ...[more]

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