Ontology highlight
ABSTRACT:
SUBMITTER: Perera MA
PROVIDER: S-EPMC3625373 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20110126 3
It is well recognized that the genetic variants VKORC1-1639, CYP2C9*2, and CYP2C9*3 contribute to warfarin dose response. This has led to warfarin dosing algorithms that include these polymorphisms and explains between 47% and 56% of variability in dose in Caucasians. However, these polymorphisms explain significantly less of the variance in dose among African Americans. In order to identify novel variations that affect warfarin dose in African Americans, we used a targeted resequencing strategy ...[more]