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Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing.

ABSTRACT: Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.

SUBMITTER: Kinnunen P

PROVIDER: S-EPMC3625966 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing.

Kinnunen Paivo P McNaughton Brandon H BH Albertson Theodore T Sinn Irene I Mofakham Sima S Elbez Remy R Newton Duane W DW Hunt Alan A Kopelman Raoul R

Small (Weinheim an der Bergstrasse, Germany) 20120605 16

Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hour ...[more]

PMID: 22674520

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