Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC3631322 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Feng Xiaoming X Wang Haikun H Takata Hiroshi H Day Timothy J TJ Willen Jessica J Hu Hui H
Nature immunology 20110501 6
The molecular mechanisms that underlie T cell quiescence are poorly understood. Here we report that mature naive CD8(+) T cells lacking the transcription factor Foxp1 gained effector phenotype and function and proliferated directly in response to interleukin 7 (IL-7) in vitro. Foxp1 repressed expression of the IL-7 receptor α-chain (IL-7Rα) by antagonizing Foxo1 and negatively regulated signaling by the kinases MEK and Erk. Acute deletion of Foxp1 induced naive T cells to gain an effector phenot ...[more]