Ontology highlight
ABSTRACT:
SUBMITTER: Dunn SJ
PROVIDER: S-EPMC4257066 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Dunn S-J SJ Martello G G Yordanov B B Emmott S S Smith A G AG
Science (New York, N.Y.) 20140601 6188
The gene regulatory circuitry through which pluripotent embryonic stem (ES) cells choose between self-renewal and differentiation appears vast and has yet to be distilled into an executive molecular program. We developed a data-constrained, computational approach to reduce complexity and to derive a set of functionally validated components and interaction combinations sufficient to explain observed ES cell behavior. This minimal set, the simplest version of which comprises only 16 interactions, ...[more]