Ontology highlight
ABSTRACT:
SUBMITTER: Leishman E
PROVIDER: S-EPMC3754479 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Leishman Erin E Howard Jeffrey M JM Garcia Gloria E GE Miao Qi Q Ku Amy T AT Dekker Joseph D JD Tucker Haley H Nguyen Hoang H
Development (Cambridge, England) 20130814 18
Hair follicles cyclically degenerate and regenerate throughout adult life and require regular stem cell activation to drive the cycle. In the resting phase of the hair cycle, hair follicle stem cells are maintained in a quiescent state until they receive signals to proliferate. We found that the forkhead transcription factor Foxp1 is crucial for maintaining the quiescence of hair follicle stem cells. Loss of Foxp1 in skin epithelial cells leads to precocious stem cell activation, resulting in dr ...[more]