Ontology highlight
ABSTRACT:
SUBMITTER: Zalatan JG
PROVIDER: S-EPMC3631425 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Zalatan Jesse G JG Coyle Scott M SM Rajan Saravanan S Sidhu Sachdev S SS Lim Wendell A WA
Science (New York, N.Y.) 20120809 6099
Cells reuse signaling proteins in multiple pathways, raising the potential for improper cross talk. Scaffold proteins are thought to insulate against such miscommunication by sequestering proteins into distinct physical complexes. We show that the scaffold protein Ste5, which organizes the yeast mating mitogen-activated protein kinase (MAPK) pathway, does not use sequestration to prevent misactivation of the mating response. Instead, Ste5 appears to use a conformation mechanism: Under basal cond ...[more]