Ontology highlight
ABSTRACT:
SUBMITTER: Kamaly N
PROVIDER: S-EPMC3631648 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Kamaly Nazila N Fredman Gabrielle G Subramanian Manikandan M Gadde Suresh S Pesic Aleksandar A Cheung Louis L Fayad Zahi Adel ZA Langer Robert R Tabas Ira I Farokhzad Omid Cameron OC
Proceedings of the National Academy of Sciences of the United States of America 20130326 16
Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation and enhance resolution are of considerable interest. In this study, we demonstrate the proresolving activity of sub-100-nm nanoparticles (NPs) containing the anti-inflammatory peptide Ac2-26, an annexin A1/lipocortin 1-mimetic peptide. These NPs were engineered using biodegrad ...[more]