Ontology highlight
ABSTRACT:
SUBMITTER: Gadde S
PROVIDER: S-EPMC4160375 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Gadde Suresh S Even-Or Orli O Kamaly Nazila N Hasija Apoorva A Gagnon Philippe G PG Adusumilli Krishna H KH Erakovic Andrea A Pal Anoop K AK Zhang Xue-Qing XQ Kolishetti Nagesh N Shi Jinjun J Shi Jinjun J Fisher Edward A EA Farokhzad Omid C OC
Advanced healthcare materials 20140324 9
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing the synthetic LXR agonist GW3965 (LXR-NPs) is demonstrated, developed from a combinatorial library of more than 70 formulations with variations in critical phy ...[more]