Ontology highlight
ABSTRACT:
SUBMITTER: Tafesse FG
PROVIDER: S-EPMC3631694 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Tafesse Fikadu G FG Sanyal Sumana S Ashour Joseph J Guimaraes Carla P CP Hermansson Martin M Somerharju Pentti P Ploegh Hidde L HL
Proceedings of the National Academy of Sciences of the United States of America 20130401 16
Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The transport of HA to the cell surface was assessed by accessibility of HA on intact cells to exogenously added trypsin and to HA-specific antibodies. Rates of de novo synthesis of viral proteins in wil ...[more]