Ontology highlight
ABSTRACT:
SUBMITTER: Miller AC
PROVIDER: S-EPMC2761761 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Miller Adam C AC Lyons Eric L EL Herman Tory G TG
Current biology : CB 20090723 16
Lateral inhibition mediated by Delta/Notch (Dl/N) signaling is used throughout development to limit the number of initially equivalent cells that adopt a particular fate. Although adjacent cells express both Dl ligand and N receptor, signaling between them ultimately occurs in only one direction. Classically, this has been explained entirely by feedback: activated N can downregulate Dl, amplifying even slight asymmetries in the Dl or N activities of adjacent cells. Here, however, we present an e ...[more]