Ontology highlight
ABSTRACT:
SUBMITTER: Kryuchkova P
PROVIDER: S-EPMC3632111 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Kryuchkova Polina P Grishin Alexander A Eliseev Boris B Karyagina Anna A Frolova Ludmila L Alkalaeva Elena E
Nucleic acids research 20130223 8
Release factor eRF1 plays a key role in the termination of protein synthesis in eukaryotes. The eRF1 consists of three domains (N, M and C) that perform unique roles in termination. Previous studies of eRF1 point mutants and standard/variant code eRF1 chimeras unequivocally demonstrated a direct involvement of the highly conserved N-domain motifs (NIKS, YxCxxxF and GTx) in stop codon recognition. In the current study, we extend this work by investigating the role of the 41 invariant and conserve ...[more]