Ontology highlight
ABSTRACT:
SUBMITTER: Bulygin KN
PROVIDER: S-EPMC3167606 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Bulygin Konstantin N KN Khairulina Yulia S YS Kolosov Petr M PM Ven'yaminova Aliya G AG Graifer Dmitri M DM Vorobjev Yuri N YN Frolova Ludmila Yu LY Karpova Galina G GG
Nucleic acids research 20110520 16
Positioning of release factor eRF1 toward adenines and the ribose-phosphate backbone of the UAAA stop signal in the ribosomal decoding site was studied using messenger RNA (mRNA) analogs containing stop signal UAA/UAAA and a photoactivatable cross-linker at definite locations. The human eRF1 peptides cross-linked to these analogs were identified. Cross-linkers on the adenines at the 2nd, 3rd or 4th position modified eRF1 near the conserved YxCxxxF loop (positions 125-131 in the N domain), but cr ...[more]