Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity.
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ABSTRACT:
SUBMITTER: Graziane NM
PROVIDER: S-EPMC3632376 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity.
Graziane Nicholas M NM Polter Abigail M AM Briand Lisa A LA Pierce R Christopher RC Kauer Julie A JA
Neuron 20130301 5
Stress facilitates reinstatement of addictive drug seeking in animals and promotes relapse in humans. Acute stress has marked and long-lasting effects on plasticity at both inhibitory and excitatory synapses on dopamine neurons in the ventral tegmental area (VTA), a key region necessary for drug reinforcement. Stress blocks long-term potentiation at GABAergic synapses on dopamine neurons in the VTA (LTPGABA), potentially removing a normal brake on activity. Here we show that blocking kappa opioi ...[more]
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