Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis.
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ABSTRACT:
SUBMITTER: Ayers CL
PROVIDER: S-EPMC3634883 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis.
Ayers Chris L CL Mendoza Jason P JP Sinha Sushmita S Cunnusamy Khrishen K Greenberg Benjamin M BM Frohman Elliot M EM Karandikar Nitin J NJ
Clinical immunology (Orlando, Fla.) 20130306 2
Daily administration of FDA-approved glatiramer acetate (GA) has beneficial effects on clinical course of relapsing remitting multiple sclerosis (RRMS). Although mechanisms of GA-action have been widely investigated and partially understood, immediate immune dynamics following GA-therapy are unknown. In the present study, we characterized the immediate effects of GA on phenotype, quantity and function of immune cells in MS patients. Prominent changes in immune cells were detected within 4-12h po ...[more]
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