Ontology highlight
ABSTRACT:
SUBMITTER: Crowe CR
PROVIDER: S-EPMC3638739 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Crowe Christopher R CR Chen Kong K Pociask Derek A DA Alcorn John F JF Krivich Cameron C Enelow Richard I RI Ross Ted M TM Witztum Joseph L JL Kolls Jay K JK
Journal of immunology (Baltimore, Md. : 1950) 20090925 8
Acute lung injury due to influenza infection is associated with high mortality, an increase in neutrophils in the airspace, and increases in tissue myeloperoxidase (MPO). Because IL-17A and IL-17F, ligands for IL-17 receptor antagonist (IL-17RA), have been shown to mediate neutrophil migration into the lung in response to LPS or Gram-negative bacterial pneumonia, we hypothesized that IL-17RA signaling was critical for acute lung injury in response to pulmonary influenza infection. IL-17RA was cr ...[more]