Ontology highlight
ABSTRACT:
SUBMITTER: Wolpin BM
PROVIDER: S-EPMC3639523 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wolpin Brian M BM Ng Kimmie K Zhu Andrew X AX Abrams Thomas T Enzinger Peter C PC McCleary Nadine J NJ Schrag Deborah D Kwak Eunice L EL Allen Jill N JN Bhargava Pankaj P Chan Jennifer A JA Goessling Wolfram W Blaszkowsky Lawrence S LS Supko Jeffrey G JG Elliot Meaghan M Sato Kaori K Regan Eileen E Meyerhardt Jeffrey A JA Fuchs Charles S CS
The oncologist 20130411 4
<h4>Background</h4>Treatments that target the vascular endothelial growth factor (VEGF) pathway have efficacy in colorectal cancer. We evaluated tolerability and efficacy of tivozanib (an oral VEGF receptor-1, -2, -3 inhibitor) plus everolimus (an oral mammalian target of rapamycin inhibitor).<h4>Methods</h4>The phase Ib study followed a 3 + 3 dose-escalation design with three dose levels. The primary objective in the follow-on phase II study was improvement in 2-month progression-free survival ...[more]