Ontology highlight
ABSTRACT:
SUBMITTER: Dronca RS
PROVIDER: S-EPMC4348017 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Dronca Roxana S RS Allred Jacob B JB Perez Domingo G DG Nevala Wendy K WK Lieser Elizabeth A T EA Thompson Michael M Maples William J WJ Creagan Edward T ET Pockaj Barbara A BA Kaur Judith S JS Moore Timothy D TD Marchello Benjamin T BT Markovic Svetomir N SN
American journal of clinical oncology 20140801 4
<h4>Objective</h4>Mammalian target of rapamycin (mTOR) pathway is activated in malignant melanoma and in situ lesions as opposed to benign nevi. Inhibition of PI3K-Akt-mTOR signaling is implicated in sensitization of melanoma cells to alkylating agents (temozolomide [TMZ]) and inhibition of tumor angiogenesis.<h4>Methods</h4>We conducted a single-arm phase II multi-institution cooperative group study to assess the antitumor activity and safety profile of the combination of TMZ and the rapamycin ...[more]