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New steroids from the soft coral Nephthea chabrolii.

ABSTRACT: A new cytotoxic 19-oxygenated steroid, nebrosteroid Q(1) and two new cytotoxic 19-norergosterols, nebrosteroids R and S (2 and 3) were isolated from the soft coral Nephthea chabrolii collected at San-Hsian-Tai. The structures of nebrosteroids Q-S (1-3) were elucidated by spectral analysis, and their cytotoxicity against selected cancer cells as well as antiviral activity against human cytomegalovirus (HCMV) were measured in vitro.

SUBMITTER: Wang SK 

PROVIDER: S-EPMC3640399 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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New steroids from the soft coral Nephthea chabrolii.

Wang Shang-Kwei SK   Puu Shyh-Yueh SY   Duh Chang-Yih CY  

Marine drugs 20130222 2

A new cytotoxic 19-oxygenated steroid, nebrosteroid Q(1) and two new cytotoxic 19-norergosterols, nebrosteroids R and S (2 and 3) were isolated from the soft coral Nephthea chabrolii collected at San-Hsian-Tai. The structures of nebrosteroids Q-S (1-3) were elucidated by spectral analysis, and their cytotoxicity against selected cancer cells as well as antiviral activity against human cytomegalovirus (HCMV) were measured in vitro. ...[more]

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