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Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites.

ABSTRACT: Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4-11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1-3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1-11 were also examined to evaluate the anti-inflammatory potential, and 2-4 were shown to exhibit significant activities.

SUBMITTER: Huang CY

PROVIDER: S-EPMC5082328 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites.

Huang Chiung-Yao CY Chang Che-Wei CW Tseng Yen-Ju YJ Lee Jessica J Sung Ping-Jyun PJ Su Jui-Hsin JH Hwang Tsong-Long TL Dai Chang-Feng CF Wang Hui-Chun HC Sheu Jyh-Horng JH

Marine drugs 20161011 10

Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4-11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds <b ...[more]

PMID: 27727166

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