Ontology highlight
ABSTRACT:
SUBMITTER: Kuo CY
PROVIDER: S-EPMC4100144 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kuo Chao-Ying CY Juan Yung-Shun YS Lu Mei-Chin MC Chiang Michael Yen-Nan MY Dai Chang-Feng CF Wu Yang-Chang YC Sung Ping-Jyun PJ
International journal of molecular sciences 20140606 6
Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells. ...[more]