The AR dependent cell cycle: mechanisms and cancer relevance.
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ABSTRACT:
SUBMITTER: Schiewer MJ
PROVIDER: S-EPMC3641823 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
The AR dependent cell cycle: mechanisms and cancer relevance.
Schiewer Matthew J MJ Augello Michael A MA Knudsen Karen E KE
Molecular and cellular endocrinology 20110712 1-2
Prostate cancer cells are exquisitely dependent on androgen receptor (AR) activity for proliferation and survival. As these functions are critical targets of therapeutic intervention for human disease, it is imperative to delineate the mechanisms by which AR engages the cell cycle engine. More than a decade of research has revealed that elegant intercommunication between AR and the cell cycle machinery governs receptor-dependent cellular proliferation, and that perturbations in this process occu ...[more]
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