Ontology highlight
ABSTRACT:
SUBMITTER: Knudsen ES
PROVIDER: S-EPMC6719339 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Trends in cancer 20190430 5
Recent studies highlight the importance of the RB1 tumor suppressor as a target for cancer therapy. Canonically, RB1 regulates cell cycle progression and represents the downstream target for cyclin-dependent kinase (CDK) 4/6 inhibitors that are in clinical use. However, newly discovered features of the RB1 pathway suggest new therapeutic strategies to counter resistance and improve precision medicine. These therapeutic strategies include deepening cell cycle exit with CDK4/6 inhibitor combinatio ...[more]