Ontology highlight
ABSTRACT:
SUBMITTER: Ovsyannikova IG
PROVIDER: S-EPMC3644318 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Ovsyannikova Inna G IG Haralambieva Iana H IH Vierkant Robert A RA O'Byrne Megan M MM Poland Gregory A GA
Human immunology 20130213 6
The role of polymorphisms within the antiviral tripartite motif (TRIM) genes in measles vaccine adaptive immune responses was examined. A limited association was found between TRIM5 (rs7122620) and TRIM25 (rs205499) gene polymorphisms and measles-specific antibody levels. However, many associations were found between TRIM gene SNPs and variations in cellular responses (IFN-γ Elispot and secreted cytokines IL-2, IL-6, IL-10, IFN-γ, and TNF-α). TRIM22 rs2291841 was significantly associated with an ...[more]