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The structural basis of ligand recognition by natural killer cell receptors.

ABSTRACT: Natural killer cells are a group of lymphocytes which function as tightly controlled surveillance operatives which identify transformed cells through a discrete balance of activating and inhibitory receptors ultimately leading to the destruction of incongruent cells. The understanding of this finely tuned balancing act has been aided by the high-resolution structure determination of activating and inhibitory receptors both alone and in complex with their ligands. This paper collates these structural studies detailing the aspects which directly relate to the natural killer cell function and serves to inform both the specialized structural biologist reader and a more general immunology audience.

SUBMITTER: Joyce MG

PROVIDER: S-EPMC3100565 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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The structural basis of ligand recognition by natural killer cell receptors.

Joyce M Gordon MG Sun Peter D PD

Journal of biomedicine & biotechnology 20110518

Natural killer cells are a group of lymphocytes which function as tightly controlled surveillance operatives which identify transformed cells through a discrete balance of activating and inhibitory receptors ultimately leading to the destruction of incongruent cells. The understanding of this finely tuned balancing act has been aided by the high-resolution structure determination of activating and inhibitory receptors both alone and in complex with their ligands. This paper collates these struct ...[more]

PMID: 21629745

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