Ontology highlight
ABSTRACT:
SUBMITTER: Michaelevski I
PROVIDER: S-EPMC3645873 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Michaelevski Izhak I Segal-Ruder Yael Y Rozenbaum Meir M Medzihradszky Katalin F KF Shalem Ophir O Coppola Giovanni G Horn-Saban Shirley S Ben-Yaakov Keren K Dagan Shachar Y SY Rishal Ida I Geschwind Daniel H DH Pilpel Yitzhak Y Burlingame Alma L AL Fainzilber Mike M
Science signaling 20100713 130
Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in lesioned peripheral sensory neurons; however, the links between axonal injury signaling and the cell body response are not well understood. Here, we used phosphoproteomics and microarrays to implicate approximately 900 phosphoproteins in retrograde injury signaling in rat sciatic nerve axons in vivo and approximately 4500 transcripts in the in vivo response to injury in the dorsal root ganglia. Computational an ...[more]