Ontology highlight
ABSTRACT:
SUBMITTER: Yan Q
PROVIDER: S-EPMC3648074 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Yan Qingrong Q Barros Tiago T Visperas Patrick R PR Deindl Sebastian S Kadlecek Theresa A TA Weiss Arthur A Kuriyan John J
Molecular and cellular biology 20130325 11
Serial activation of the tyrosine kinases Lck and ZAP-70 initiates signaling downstream of the T cell receptor. We previously reported the structure of an autoinhibited ZAP-70 variant in which two regulatory tyrosine residues (315 and 319) in the SH2-kinase linker were replaced by phenylalanine. We now present a crystal structure of ZAP-70 in which Tyr 315 and Tyr 319 are not mutated, leading to the recognition of a five-residue sequence register error in the SH2-kinase linker of the original cr ...[more]