Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy.
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ABSTRACT:
SUBMITTER: Durovic B
PROVIDER: S-EPMC3648112 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy.
Durovic Bojana B Gasser Olivier O Gubser Patrick P Sigle Jörg J Hirsch Hans H HH Stern Martin M Buser Andreas A Hess Christoph C
Journal of virology 20130327 11
Epstein-Barr virus (EBV) infects ≈ 95% of the adult population. The factors that confer protection in the remaining ≈ 5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 years. Analyses of HLA genotypes revealed an association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4 alleles. In addition, EBV-negative donors presented with a history of tonsillec ...[more]
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